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Laugh lines may be the shadows of former smiles, but if you’ve noticed your eye crinkles, forehead frown lines and mouth “parenthesis” are lingering—after your emotions have faded—it’s time for some rogue wrinkle wrangling with targeted, state-of-the-art skin care.

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ESTEE LAUDER ADVANCED NIGHT REPAIR maximizes the power of skin’s natural nighttime renewal, dramatically reducing the look for all key signs of aging. 25+ patents and pending worldwide.

1 oz. $62, esteelauder.com

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iS CLINICAL YOUTH SERUM  is said to provide instant smoothing and tightening with dramatic wrinkle reduction over time— using intelligent proteins, bio-identical growth factors, and a powerful blend of antioxidants.

1 oz. $150, dermstore.com

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ALGENIST ADVANCED WRINKLE FIGHTING SERUM  features patented Alguronic Acid with Peptide 3D Complex to visibly minimize the size and depth of the deepest wrinkles.

1 oz. $105, sephora.com

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OLAY REGENERIST REGENERATING SERUM  is a lightweight serum with an advanced amino peptide complex to quickly regenerate surface cells and create softer, smoother looking skin $24.99, available at Walgreens, CVS and drugstores and supermarkets nationwide.

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ACURE RADICAL WRINKLE COMPLEX contains a concentrated blend of organic chlorella growth factor, gardenia and argan stem cells, and cold pressed argan oil to boost collagen, stimulate new cell growth and smooth lines.

1.4 oz. 24.99, acureorganics.com

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ROC RETINOL CORREXION MAX WRINKLE RESURFACING SYSTEM is a deep wrinkle solution clinically proven to be up to 4X more effective than a series of three dermatologist administered peels. $29.99 at cvs.com. For additional retailers,  visit rocskincare.com

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